Prednisone for Dogs: Uses & Side Effects
Veterinary references checked with PetHealth+ · Last reviewed June 2026
By Kaiser Khan , Founder Veterinary references checked with PetHealth+ ( process ) Last reviewed Cite this page How we research & review
Prednisone treats allergies, autoimmune disease, and some cancers. Never stop abruptly after long courses — taper under vet supervision to avoid adrenal crisis.
Benefits
Powerful anti-inflammatory and immunosuppressive effects.
Side effects
Increased thirst, hunger, panting, and infection risk with long use.
Tapering
Essential after prolonged therapy.
Related: Dog allergies · Apoquel for dogs
Frequently asked questions
Does prednisone make dogs drink more?
Yes — polyuria and polydipsia are common.
Can prednisone cause behaviour changes?
Restlessness and increased appetite occur in some dogs.
Is short-term prednisone safe?
Brief courses for flare-ups are common — follow your vet's schedule.
Can prednisone interact with other drugs?
Yes — including NSAIDs; never combine without vet approval.